Sleep Apnea
Medications
Related eMedTV
Health Channels

Drug Interactions With Modafinil

Several medications may cause potentially dangerous drug interactions with modafinil, including rifamycin antibiotics, propranolol, and monoamine oxidase inhibitors. These interactions can increase or decrease drug levels in your blood, which could either increase your risk for side effects or reduce the effectiveness of the medicines. Other medications that may cause drug interactions with modafinil include cyclosporine, tricyclic antidepressants, and certain antifungals or antibiotics.

 

Drug Interactions With Modafinil: An Overview

Modafinil (Provigil®) can potentially interact with several other medicines. Some of the medicines that may lead to drug interactions with modafinil include:
 
  • Certain antibiotics or antifungals, such as:
 
    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®)
 
  • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
  • Diazepam (Valium®)
  • Estrogen-containing medications, including birth control pills, patches, or rings
  • Monoamine oxidase inhibitors (MAOIs), such as:
 
 
  • Propranolol (Inderal®, Inderal® LA)
  • Rifamycin antibiotics, such as rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
  • Seizure medications
  • Some protease inhibitors, such as:
 
 
 
 
  • Warfarin (Coumadin®, Jantoven®).
     
(Drug Interactions With Modafinil Continued: Page 2)
Add this article to your Favorites     Email this article     Print
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;