Drug Interactions With Modafinil
Propranolol (Inderal, Inderal LA)
Taking propranolol with modafinil can increase the level of propranolol in your blood, possibly increasing the chance of side effects. Check with your healthcare provider before taking these two medications together.
Rifamycin antibiotics may decrease the level of modafinil in your blood, perhaps making it less effective. Contact your healthcare provider if you notice that modafinil seems to be less effective since starting a rifamycin antibiotic.
Check with your healthcare provider before taking modafinil with any seizure medications. Some seizure medications may decrease the level of modafinil in your blood, and modafinil may increase the level of some seizure medications in your blood.
Some Protease Inhibitors
Some protease inhibitors may increase the level of modafinil in your blood, possibly increasing your risk of side effects of modafinil. Check with your healthcare provider before taking modafinil with a protease inhibitor.
Combining a tricyclic antidepressant with modafinil may increase the level of the antidepressant in your blood, possibly increasing your risk of side effects. Your healthcare provider may need to lower the dose of your tricyclic antidepressant to prevent drug interactions from occurring.
Warfarin (Coumadin, Jantoven)
Modafinil may interact with warfarin. Your healthcare provider may need to monitor you more closely and adjust your warfarin dosage as necessary, especially when you start or stop taking modafinil.
It is possible that not all drug interactions with modafinil were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific drug interactions that may apply to you.