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Drug Interactions With Modafinil

Modafinil Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when modafinil is combined with any of the drugs listed above.
Certain Antibiotics or Antifungals
Combining modafinil with certain antibiotics or antifungals may increase the level of modafinil in your blood. Your healthcare provider may recommend that you take a lower modafinil dosage. Check with your healthcare provider before taking modafinil with any of these medications.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Modafinil may decrease the level of cyclosporine in your blood, perhaps making it less effective. If you take these two medications together, your healthcare provider may need to measure the level of cyclosporine in your blood and adjust your dose as necessary.
Diazepam (Valium)
Modafinil may increase the level of diazepam in your blood, possibly increasing the risk of side effects. Your healthcare provider may need to lower the dose of diazepam if you are taking both of these medications.
Estrogen-Containing Medications
Modafinil can decrease the level of estrogen medications in the blood. This can be especially important for women taking birth control pills, patches, or rings, as these forms of birth control may be less effective if combined with Modafinil. You should use an alternative or backup form of contraception (such as condoms) while taking modafinil and for at least one month after starting the drug.
Monoamine Oxidase Inhibitors (MAOIs)
It is not known if it is safe to take modafinil with an MAOI. Since medications similar to modafinil interact dangerously with MAOIs, you should avoid taking modafinil with an MAOI until more information is available.

Modafinil Drug Information

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