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Several medicines may cause negative drug interactions with armodafinil, including many antibiotics or antifungals, tricyclic antidepressants, some protease inhibitors, and seizure medications. These interactions can increase or decrease the drug levels in your blood, which could either increase your risk for side effects or decrease the effectiveness of the medicines. If drug interactions with armodafinil are a concern, your healthcare provider may adjust your dosages.

Drug Interactions With Armodafinil: An Overview

Armodafinil (Nuvigil™) can potentially interact with several other medicines. Some of the medicines that may lead to drug interactions with armodafinil include:
    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®)
  • Monoamine oxidase inhibitors (MAOIs), such as:
  • Propranolol (Inderal®, Inderal® LA)
  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
  • Seizure medications
  • Some protease inhibitors, such as:
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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